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ea0063gp176 | Benign Thyroid Disorders | ECE2019

Do different initial doses of L-T4 within the range of 10–15 mcg/kg/die influence neurodevelopment during the first two years of life in children with congenital hypothyroidism?

Moracas Cristina , Ciccarelli Gian Paolo , Bravaccio Carmela , Cassio Alessandra , Gastaldi Roberto , Mussa Alessandro , Polizzi Miriam , Vigone Maria Cristina , Wasniewska Malgorzata Gabriela , Weber Giovanna , Salerno Mariacarolina

Background: The initial L-T4 dose in the treatment of congenital hypothyroidism (CH) currently recommended is 1015 mcg/kg/die.Objective: We designed a multicenter randomized trial to evaluate the effects of different starting dose of L-T4 within the range 1015 mcg/kg/die on neurocognitive development in children with CH.Methods: Seventy-two children with CH diagnosed by neonatal screening were enrolled in the study. The...

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Endocrine Abstracts

Do different initial doses of L-T4 within the range of 10–15 mcg/kg/die influence neurodevelopment during the first two years of life in children with congenital hypothyroidism?

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